This study was devoted to the study of changes in the biochemical composition of the blood of sows with hepatopathy (acute and chronic hepatosis, liver cirrhosis). Groups of sows were formed on the basis of macroscopic changes in the liver, identified during their post-mortem examination. Blood for biochemical research was taken from sows before slaughter. The studied blood biochemical parameters were grouped into 4 serum biochemical syndromes of liver diseases: inflammatory-mesenchymal, hepatodepressive, cytolytic and cholestatic. Changes in the blood composition of sows, characterizing the inflammatory-mesenchymal syndrome, were established in all studied hepatopathy. A positive thymol test, a decrease in the albumin-globulin ratio, an increase in the concentration of globulins were caused by dysproteinemia. Its development is associated not only with inflammatory, but also with dystrophic, necrobiotic and necrotic changes in the liver. The most significant decrease in these indicators was found in liver cirrhosis. Cytolytic changes were established in all studied hepatopathy. To a greater extent, these changes (increased activities of transaminases, bilirubin concentration) were expressed in the blood of sows with acute hepatosis. With cholestasis syndrome, a number of typical changes were absent in the blood, which was due to a decrease in the formation of cholesterol and direct bilirubin in the liver in chronic hepatosis and cirrhosis. An increase in the activities of γ-glutamyl transpeptidase (higher than the reference values) and alkaline phosphatase (in comparison with the indicators of sows without signs of hepatopathy) were more pronounced in the blood of animals with signs of chronic hepatosis and liver cirrhosis. The data obtained indicate severe metabolic disorders in sows with the development of chronic hepatopathy. The results of the research can be used in diagnostic work and in monitoring the effectiveness of ongoing therapeutic and preventive measures.

Petrovskii Sergei V., Kotovich Igor V.

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