More than 10 zeolite deposits have been explored in the Amur region. A distinctive feature of the zeolites of the Vanginskoe deposit is the high content of one of the most effective zeolite components (clinoptilolite + geylandite), while at the same time having a low content of substances dangerous to the body (arsenic, mercury, cadmium and radioactive elements). The drugs "Tsesamin" and "Vangtseyod" have been developed on the basis of zeolites from the Wanginsky deposit. The aim of the research was to study the harmlessness and effectiveness of these drugs for the prevention and treatment of digestive diseases in piglets at weaning and the prevention of iodine deficiency in pregnant сows and their offspring. The safety of the drugs is confirmed by the absence of acute and chronic toxicity to laboratory animals. The drugs are classified as class IV (low-risk substances). The complex preparation "Tsesamin" (at a dose of 2 g/kg of body weight) has an antimicrobial, anti-stress effect. It helps to normalize metabolic processes, increase the immune status of animals, eliminate toxins from the gastrointestinal tract, and does not cause the formation of resistance in opportunistic microflora. The drug has hepatoprotective and antioxidant properties. Using it for preventive and curative purposes in weaned piglets helps to significantly reduce their gastrointestinal disorders. Feeding of the iodine-containing drug "Vangtseyod" at a dose of 0.2 g/kg of body weight for 60 days to pregnant cows contributed to the normalization of metabolic processes and increased immune status. There was a significant increase in phagocytic activity by 10.9% and an increase in the phagocytic number by 1.1 times. The indicators of the humoral protection link in calves born from these cows were higher in comparison with the control. At the same time, there was an increase in immunoglobulins by 13%, the titer of normal antibodies
by 68.4%, circulating immune complexes by 1.6 times, and lysozyme activity by 22.6%.

Kruchinkina Tatyana V.

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