The development of green synthesis methods for the production of safe and biocompatible nanomaterials is a key task of nanotechnology. The use of probiotic cultures for the synthesis of selenium nanoparticles is of scientific and practical importance. This makes it possible to combine the beneficial properties of probiotics with the unique biological activity of the microelement nanoform. The aim of the research is the synthesis and characterization of selenium nanoparticles obtained using probiotic bacteria Bifidobacterium adolescentis DSM20083 and Propionibacterium shermanni AC2503. Nanoselenium biosynthesis was performed by incubating bacterial cells with sodium selenite (Na2SeO3). The resulting nanoparticles were characterized using transmission electron microscopy and laser diffraction. It has been established that probiotic strains reduce sodium selenite to elementary selenium with the formation of spherical amorphous nanoparticles stabilized by biomolecules. The possibility of obtaining stable and biologically active selenium nanoparticles using probiotic strains has been shown for the first time. It is proved that biogenic nanoselenium has low toxicity. This makes it promising for the creation of synergistic probiotic drugs and functional food products of a new generation.

Khamagaeva Irina S., Kachanina Lyudmila M., Zambalova Natalya A., Stolyarova Anna S.

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