Experimental modeling of oxidative stress is an important component of pharmacological studies at the preclinical stage. The article presents the results of approbation of the model of the impact of a low-frequency alternating magnetic field in comparison with the previously proven model of the influence of high temperatures on a warm-blooded organism. For the experiment, 4 groups of laboratory animals were formed, 30–36 rats each. The advantages of the model of oxidative stress formation under the influence of a magnetic field are confirmed by a more pronounced accumulation of lipid peroxidation products in the blood plasma and liver tissue of rats compared to intact animals and rats subjected to hyperthermia. The influence of the magnetic field on rats was accompanied by a statistically significant excess of the level of diene conjugates relative to intact rats by 17–21 % in blood plasma and by 36–43 % in liver tissue (p<0.05). The concentration of lipid hydroperoxides under magnetic induction increased by 14–20 % in blood plasma and 30–32 % in liver tissue compared with the intact group (p<0.05). More pronounced dynamics was demonstrated by the secondary product of lipid peroxidation – malon dialdehyde, the accumulation of which was statistically significantly higher in animals exposed to high temperatures. Thus, the advantages of the model of oxidative stress formation under the influence of a low-frequency alternating magnetic field have been experimentally confirmed.

Panfilov Stepan V., Miller Tatyana V., Simonova Natalia V., Sayapina Irina Yu., Lashin Anton P.

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