The analysis of correlations between the parameters of the antioxidant status and some hematological parameters in laboratory animals under ultraviolet irradiation and the administration of succinate-containing preparations was carried out using the Pearson correlation criterion. It was established that the administration of succinic acid in laboratory animals at a dose of 100 mg/kg daily intraperitoneally for 14 days under ultraviolet irradiation promoted the formation of strong inverse correlations between the degree of accumulation of malondialdehyde and the number of erythrocytes, hemoglobin, platelets. The use of succinic acid made it possible to establish a strong interaction between ceruloplasmin, catalase and erythrocytes, platelets, which indicated the normalization of hematological parameters with an increase in the activity of the antioxidant system. In comparison with succinic acid, the use of Reamberin was distinguished by the formation of correlations that were larger in number and more expressed in strength. The administration of the combined preparation at a dose of 100 mg/kg of succinate intraperitoneally daily for 14 days was accompanied by a correlation dependence between malondialdehyde and erythrocytes, hemoglobin, platelets and leukocytes. In addition, when using Reamberin, a strong direct relationship was established in three pairs – catalase with the number of erythrocytes, hemoglobin and platelets. Thus, the results of the correlation analysis make it possible to state an increase in the strength of the relationship between the parameters of the antioxidant status and hematological parameters upon administration of succinate-containing preparations, which confirms the antioxidant properties of succinic acid, which is capable of correcting pathological changes in the homeostasis system.

Lashin Anton P., Simonova Natalia V., Sayapina Irina Yu.

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