Finding effective methods for replenishing mineral deficiency in farm animals in Amur region is very relevant. Studies were conducted to study a new mineral feed additive chronic toxicity in white rats. The following doses of the feed additive were tested (g/kg): 1.0 (I experimental group), 2.0 (II experimental group), 5.0 (III experimental group) for 60 days. Animals in control group did not receive feed additive. The hematological and biochemical composition of blood was analyzed. The live weight of experimental animals was determined. Organ mass coefficients were calculated. As a result of the research, it was established that mineral feed additive, when fed for a long time in the above doses, did not have toxic effect on body of white rats, as evidenced by: 100% survival of experimental animals, their satisfactory general condition and high intensity of live weight gain by 16.6; 21.0; 18.4% versus 15.2% in the control. Also, the absence of toxic effects of used additive was indicated by the uniform dynamics of biochemical blood parameters and the absence of significant intergroup differences, with the exception of glucose concentration. Glucose concentration increased in proportion to the increase in the dose of the studied additive by 33.3% (p <0.05), 49.7% (p <0.01) in groups II and III, respectively, which was due to the effect of calcium propionate. A study of the pathological picture and mass coefficients of internal organs did not reveal any abnormalities.

Kruchinkina Tatyana V., Ostyakova Marina E.

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